This paper is also available at: https://doi.org/10.5281/zenodo.21783658 Abstract Microplastics and nanoplastics (MPs/NPs) can interact with biological systems through multiple mechanisms that may affect the central nervous system, including immune activation, blood-brain barrier dysfunction, oxidative stress, mitochondrial dysfunction, cytokine signaling, disrupted autophagy/proteostasis, neuronal injury, and gut-brain axis disruption. These pathways are biologically plausi

Abstract Airborne microplastics (MPs) and nanoplastics (NPs) are increasingly recognized as an important route of environmental exposure. Recent studies have identified microplastics within the human olfactory bulb and have demonstrated associations between environmental particulate exposure, inflammation, oxidative stress, and neurological injury. These findings suggest that the nasal cavity may represent an important site for therapeutic intervention. This Technical Note

Executive Summary The FDA’s AI-Enabled Optimization of Early-Phase Clinical Trials Pilot Program offers a valuable opportunity to test how artificial intelligence can accelerate pharmaceutical development while preserving rigorous scientific and regulatory standards. This Technical Note proposes that early pilot programs may achieve the greatest long-term impact by initially focusing on therapeutically simpler but broadly representative platforms, such as topical products and

Abstract Microplastics and nanoplastics (MNPs) are increasingly recognized as environmental contaminants with potential cardiovascular relevance. Recent studies have identified MNPs in human blood, arterial tissue, and atherosclerotic plaques, raising concern that chronic exposure may contribute to vascular injury and disease progression. Clinical evidence has reported associations between MNP-positive atherosclerotic plaques and higher observed rates of major adverse cardiov

Extreme environments, whether they be the frigid temperatures of Antarctica, the scorching heat of deserts, or the high altitudes of mountainous regions, present unique challenges to human health and well-being. As our world continues to explore these harsh terrains, the need for effective therapeutic interventions becomes increasingly critical. This blog post delves into the latest advancements in therapeutic approaches tailored for extreme conditions, highlighting innovativ

The intersection of biotechnology and environmental health is becoming increasingly crucial as we face a growing number of environmental diseases. From air pollution to water contamination, the impact of our environment on human health is undeniable. Fortunately, innovative biotech solutions are emerging to combat these challenges, offering hope for a healthier future. In this blog post, we will explore various biotech approaches to environmental disease prevention, highlight

The exploration of space has always been a frontier of human curiosity and ambition. However, as we venture further into the cosmos, we encounter unique health challenges that require innovative solutions. Cythera Bio is at the forefront of addressing these challenges through groundbreaking research and technology. This blog post will explore how Cythera Bio is revolutionizing health in space, the specific challenges faced by astronauts, and the innovative solutions being dev